Msezane uses interdisciplinary practice, encompassing photography, painting, live works/embodiments, film, sculpture, and installation. Msezane creates commanding works, heavy with spiritual and political symbolism. The artist explores issues around spirituality, commemoration and African knowledge systems. Msezane’s work has been widely exhibited across South Africa and internationally, including the 17th edition of Cuenca Biennial 2025; the 14th edition of PhotoIreland; the13th Bamako Encounters African Biennale of Photography (2022); and the 14th Dak’art Biennale (2022). Her work has also been exhibited at Zeitz MOCAA (Cape Town), the Iziko South African National Gallery (Cape Town), The Royal Ontario Museum (Canada), and Oscar Niemeyer Museum (Brazil), amongst others.